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1

The Hallmarks of Aging

López-Otín, Carlos, Blasco, Maria A., Partridge, Linda, Serrano, Manuel, Kroemer, Guido

Journal:

Year:

2013

Language:

english

File:

PDF, 2.81 MB

english, 2013

2

Progeria: A Paradigm for Translational Medicine

Gordon, Leslie B., Rothman, Frank G., López-Otín, Carlos, Misteli, Tom

Journal:

Year:

2014

Language:

english

File:

PDF, 852 KB

english, 2014

3

NF-κB activation impairs somatic cell reprogramming in ageing

Soria-Valles, Clara, Osorio, Fernando G., Gutiérrez-Fernández, Ana, De Los Angeles, Alejandro, Bueno, Clara, Menéndez, Pablo, Martín-Subero, José I., Daley, George Q., Freije, José M. P., López-Otín,

Journal:

Nature Cell Biology

Year:

2015

Language:

english

File:

PDF, 3.11 MB

english, 2015

4

Decelerating ageing and biological clocks by autophagy

Lopez-Otín, Carlos, Kroemer, Guido

Journal:

Nature Reviews Molecular Cell Biology

Year:

2019

Language:

english

File:

PDF, 503 KB

english, 2019

5

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

Xiaomu Wei, Angela Moncada-Pazos, Santiago Cal, Clara Soria-Valles, Jared Gartner, Udo Rudloff, Jimmy C. Lin, NISC Comparative Sequencing Program, Steven A. Rosenberg, Carlos López-Otín, Yardena Samue

Journal:

Year:

2011

Language:

english

File:

PDF, 874 KB

english, 2011

6

Structure and expression inE. coliof the gene coding for protein p10 of African swine fever virus

M. Muñoz, J. M. P. Freije, M. L. Salas, E. Viñuela, C. López-Otín

Journal:

Archives of Virology

Year:

1993

Language:

english

File:

PDF, 1.88 MB

english, 1993

7

Protease degradomics: A new challenge for proteomics

López-Otín, Carlos, Overall, Christopher M.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2002

Language:

english

File:

PDF, 1.65 MB

english, 2002

8

Proteases: Multifunctional Enzymes in Life and Disease

Lopez-Otin, C., Bond, J. S.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 270 KB

english, 2008

9

High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus

Freije, JoséM.P., Muñoz, Maribel, Viñuela, Eladio, López-Otín, Carlos

Journal:

Year:

1993

Language:

english

File:

PDF, 469 KB

english, 1993

10

Use of a Multiple-Enzyme/Multiple-Reagent Assay System To Quantify Activity Levels in Samples Containing Mixtures of Matrix Metalloproteinases

Rasmussen, Fred H., Yeung, Nolan, Kiefer, Laura, Murphy, Gillian, Lopez-Otin, Carlos, Vitek, Michael P., Moss, Marcia L.

Journal:

Year:

2004

Language:

english

File:

PDF, 106 KB

english, 2004

11

The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer

Moncada-Pazos, A., Obaya, A. J., Fraga, M. F., Viloria, C. G., Capella, G., Gausachs, M., Esteller, M., Lopez-Otin, C., Cal, S.

Journal:

Journal of Cell Science

Year:

2009

Language:

english

File:

PDF, 1.40 MB

english, 2009

12

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

Llamazares, M., Obaya, A. J., Moncada-Pazos, A., Heljasvaara, R., Espada, J., Lopez-Otin, C., Cal, S.

Journal:

Journal of Cell Science

Year:

2007

Language:

english

File:

PDF, 1.92 MB

english, 2007

13

Molecular mechanisms of normal and pathological aging

López-Otín, Carlos

Journal:

Orphanet Journal of Rare Diseases

Year:

2015

Language:

english

File:

PDF, 260 KB

english, 2015

14

Metabolic Control of Longevity

López-Otín, Carlos, Galluzzi, Lorenzo, Freije, José M.P., Madeo, Frank, Kroemer, Guido

Journal:

Year:

2016

Language:

english

File:

PDF, 2.24 MB

english, 2016

15

Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells

Maloberti, Paula M., Duarte, Alejandra B., Orlando, Ulises D., Pasqualini, María E., Solano, Ángela R., López-Otín, Carlos, Podestá, Ernesto J., Santos, Janine

Journal:

Year:

2010

Language:

english

File:

PDF, 1.68 MB

english, 2010

16

Carbotoxicity—Noxious Effects of Carbohydrates

Kroemer, Guido, López-Otín, Carlos, Madeo, Frank, de Cabo, Rafael

Journal:

Year:

2018

Language:

english

File:

PDF, 1.20 MB

english, 2018

17

Withdrawal: Dm1 -MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development.

Llano, Elena, Pendás, Alberto M., Aza-Blanc, Pedro, Kornberg, Thomas B., López-Otín, Carlos

Journal:

Journal of Biological Chemistry

Year:

2019

Language:

english

File:

PDF, 58 KB

english, 2019

18

Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx

Cazorla, Maite, Hernández, Luis, Nadal, Alfons, Balbín, Milagros, López, José M., Vizoso, Francisco, Fernández, Pedro L., Iwata, Kazushi, Cardesa, Antonio, López-Otín, Carlos, Campo, Elías

Journal:

The Journal of Pathology

Year:

1998

Language:

english

File:

PDF, 324 KB

english, 1998

19

Néstor–Guillermo progeria syndrome: A novel premature aging condition with early onset and chronic development caused by BANF1 mutations

Rubén Cabanillas, Juan Cadiñanos, José A.F. Villameytide, Mercedes Pérez, Jesús Longo, José M. Richard, Rebeca Álvarez, Noelia S. Durán, Rafael Illán, Daniel J. González, Carlos López-Otín

Journal:

American Journal of Medical Genetics Part A

Year:

2011

Language:

english

File:

PDF, 943 KB

english, 2011

20

Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium

Otso Lindy, Yrjö T. Konttinen, Timo Sorsa, Yanli Ding, Seppo Santavirta, Arnoldas Ceponis, Carlos López-otín

Journal:

Arthritis & Rheumatism

Year:

1997

Language:

english

File:

PDF, 1.01 MB

english, 1997

21

Matrix Metalloproteinase-19 Expression in Dermal Wounds and by Fibroblasts in Culture

Hieta, Niina, Impola, Ulla, Lopez-Otin, Carlos, Saarialho-Kere, Ulpu, Kahari, Veli-Matti

Journal:

The Journal of Investigative Dermatology

Year:

2003

Language:

english

File:

PDF, 1.89 MB

english, 2003

22

Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium

Zaragoza, Carlos, Balbin, Milagros, Lopez-Otin, Carlos, Lamas, Santiago

Journal:

Kidney International

Year:

2002

Language:

english

File:

PDF, 927 KB

english, 2002

23

Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain

Santiago Cal, Juan R Peinado, María Llamazares, Víctor Quesada, Angela Moncada-Pazos, Cecilia Garabaya, Carlos López-Otín

Journal:

BMC Biochemistry

Year:

2006

Language:

english

File:

PDF, 1.38 MB

english, 2006

24

Inhibitory effects of human cystatin C on plum pox potyvirus proteases

Juan Antonio García, María Teresa Cervera, José Luis Riechmann, Carlos López-Otín

Journal:

Plant Molecular Biology

Year:

1993

Language:

english

File:

PDF, 426 KB

english, 1993

25

A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level

Milagros Balbín, José P. Freije, Magnus Abrahamson, Gloria Velasco, Anders Grubb, Carlos López-Otín

Journal:

Year:

1993

Language:

english

File:

PDF, 265 KB

english, 1993

26

Rye chromosome arm 3RS encodes a homodimeric inhibitor of insect α-amylase

G. García-Casado, R. Sánchez-Monge, C. Lopez-Otín, G. Salcedo

Journal:

Theoretical and Applied Genetics

Year:

1994

Language:

english

File:

PDF, 732 KB

english, 1994

27

Mapping and sequence of the gene encoding protein p37, A major structural protein of African swine fever virus

C. López-Otín, C. Simón, E. Méndez, E. Viñuela

Journal:

Year:

1988

Language:

english

File:

PDF, 849 KB

english, 1988

28

Prostate specific antigen — a new constituent of breast cyst fluid

Eleftherios P. Diamandis, He Yu, Carlos López-Otín

Journal:

Breast Cancer Research and Treatment

Year:

1996

Language:

english

File:

PDF, 431 KB

english, 1996

29

Factors affecting protein composition of breast secretions from nonlactating women

Francisco Vizoso, Luis M. Sánchez, Irene Díez-Itza, M. Luz Lamelas, Carlos López-Otín

Journal:

Breast Cancer Research and Treatment

Year:

1992

Language:

english

File:

PDF, 813 KB

english, 1992

30

Matrix metalloproteinases as emerging targets for cancer therapy

José A. Uría, Carlos López-Otín

Journal:

Clinical and Translational Oncology

Year:

2000

File:

PDF, 406 KB

2000

31

Autophagy: molecular mechanisms, physiological functions and relevance in human pathology

G. Mariño, C. López-Otín

Journal:

Cellular and Molecular Life Sciences

Year:

2004

Language:

english

File:

PDF, 386 KB

english, 2004

32

Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions

C. L. Ramírez, J. Cadiñanos, I. Varela, J. M. P. Freije, C. López-Otín

Journal:

Cellular and Molecular Life Sciences

Year:

2007

Language:

english

File:

PDF, 430 KB

english, 2007

33

The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities

Angela Moncada-Pazos, Alvaro J. Obaya, Cristina G. Viloria, Carlos López-Otín, Santiago Cal

Journal:

Journal of Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 477 KB

english, 2011

34

Accelerated ageing: from mechanism to therapy through animal models

Fernando G. Osorio, Álvaro J. Obaya, Carlos López-Otín, José M. P. Freije

Journal:

Transgenic Research

Year:

2009

Language:

english

File:

PDF, 321 KB

english, 2009

35

Wheat flour peroxidase is a prominent allergen associated with baker's asthma

R. SÁNCHEZ-MONGE, G. GARCÍA-CASADO, C. LÓPEZ-OTÍN†, A. ARMENTIA, G. SALCEDO

Journal:

Clinical & Experimental Allergy

Year:

1997

Language:

english

File:

PDF, 2.66 MB

english, 1997

36

Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice

F. De Carlos, I. Varela, A. Germanà, G. Montalbano, J. M. P. Freije, J. A. Vega, C. López-Otin, J. M. Cobo

Journal:

Journal of Anatomy

Year:

2008

Language:

english

File:

PDF, 3.42 MB

english, 2008

37

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Fernando G. Osorio, Ignacio Varela, Ester Lara, Xose S. Puente, Jesús Espada, Raffaella Santoro, José M. P. Freije, Mario F. Fraga, Carlos López-Otín

Journal:

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

38

Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies

Emma Pirilä, Jarkko T Korpi, Timo Korkiamäki, Tiina Jahkola, Ana Gutierrez-Fernandez, Carlos Lopez-Otin, Ulpu Saarialho-Kere, Tuula Salo, Timo Sorsa

Journal:

Wound Repair and Regeneration

Year:

2007

Language:

english

File:

PDF, 3.94 MB

english, 2007

39

Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors

MILAGROS BALBÍN, ALBERTO M. PENDÁS, JOSÉ A. URÍA, MARIA G. JIMÉNEZ, JOSÉ P. FREIJE, CARLOS LÓPEZ-OTÍN

Journal:

Year:

1999

Language:

english

File:

PDF, 1.30 MB

english, 1999

40

Evaluation of Some Newer Matrix Metalloproteinases

GILLIAN MURPHY, VERA KNÄUPER, SUSAN COWELL, ROSALIND HEMBRY, HEATHER STANTON, GEORGINA BUTLER, JOSÉ FREIJE, ALBERTO M. PENDÁS, CARLOS LÓPEZ-OTÍN

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 994 KB

english, 1999

41

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53

Ugalde, Alejandro P, Ramsay, Andrew J, de la Rosa, Jorge, Varela, Ignacio, Mariño, Guillermo, Cadiñanos, Juan, Lu, Jun, Freije, José MP, López-Otín, Carlos

Journal:

The EMBO Journal

Year:

2011

Language:

english

File:

PDF, 1.86 MB

english, 2011

42

The Urokinase Plasminogen Activator Receptor–Associated Protein/Endo180 Is Coexpressed with Its Interaction Partners Urokinase Plasminogen Activator Receptor and Matrix Metalloprotease-13 during Osteogenesis

Engelholm, Lars Henning, Nielsen, Boye Schnack, Netzel-Arnett, Sarah, Solberg, Helene, Chen, Xiao-Dong, Lopez Garcia, Jose Manuel, Lopez-Otin, Carlos, Young, Marian Francis, Birkedal-Hansen, Henning,

Journal:

Laboratory Investigation

Year:

2001

Language:

english

File:

PDF, 2.42 MB

english, 2001

43

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice

Balbín, Milagros, Fueyo, Antonio, Tester, Angus M, Pendás, Alberto M, Pitiot, Ana S, Astudillo, Aurora, Overall, Christopher M, Shapiro, Steven D, López-Otín, Carlos

Journal:

Nature Genetics

Year:

2003

Language:

english

File:

PDF, 902 KB

english, 2003

44

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice

Pendás, Alberto M., Zhou, Zhongjun, Cadiñanos, Juan, Freije, José M.P., Wang, Jianming, Hultenby, Kjell, Astudillo, Aurora, Wernerson, Annika, Rodríguez, Francisco, Tryggvason, Karl, López-Otín, Carlo

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 866 KB

english, 2002

45

Emerging roles of proteases in tumour suppression

López-Otín, Carlos, Matrisian, Lynn M.

Journal:

Nature Reviews Cancer

Year:

2007

Language:

english

File:

PDF, 556 KB

english, 2007

46

The regulatory crosstalk between kinases and proteases in cell cancer

López-Otín, Carlos, Hunter, Tony

Journal:

Nature Reviews Cancer

Year:

2010

Language:

english

File:

PDF, 783 KB

english, 2010

47

Strategies for mmp inhibition in cancer: innovations for the post-trial era

Overall, Christopher Mark, López-Otín, Carlos

Journal:

Nature Reviews Cancer

Year:

2002

Language:

english

File:

PDF, 4.30 MB

english, 2002

48

Human and mouse proteases: a comparative genomic approach

Puente, Xose S., Sánchez, Luis M., Overall, Christopher M., López-Otín, Carlos

Journal:

Nature Reviews Genetics

Year:

2003

Language:

english

File:

PDF, 2.07 MB

english, 2003

49

Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1

Ala-aho, Risto, Johansson, Nina, Grénman, Reidar, Fusenig, Norbert E, López-Otín, Carlos, Kähäri, Veli-Matti

Journal:

Year:

2000

Language:

english

File:

PDF, 462 KB

english, 2000

50

A functional link between the tumour suppressors ARF and p33ING1

González, L, Freije, J M P, Cal, S, López-Otín, C, Serrano, M, Palmero, I

Journal:

Year:

2006

Language:

english

File:

PDF, 191 KB

english, 2006

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